Toll-like receptors (TLRs) - the first barrier in innate immune response - are powerful regulators of inflammatory pathways. TollDB collects all known small molecule TLR modulators and their pharmacological properties in a structured and comprehensive manner. Currently tollDB contains 4925 datapoints describing 2155 compounds tested in 36 assay types using 553 different assay conditions.
Toll-like receptor signaling. Overview on human Toll-like receptors and their intracellular signaling pathways according to O'Neill et al., Nat Immunol, 2013 .